L-Hydroxyproline Cas: 51-35-4 Funfun lulú
| Nọmba katalogi | XD90292 |
| Orukọ ọja | L-Hydroxyproline |
| CAS | 51-35-4 |
| Ilana molikula | C5H9NO3 |
| Òṣuwọn Molikula | 131.13 |
| Awọn alaye ipamọ | Ibaramu |
| Ti irẹpọ Owo idiyele koodu | 2933998040 |
Ọja Specification
| Ayẹwo | 99% |
| Ifarahan | funfun lulú |
Idiopathic pulmonary fibrosis ni a ro pe o kan ipalara ẹdọfóró ti o fa nipasẹ awọn eya atẹgun ti o ni ifaseyin (ROS), eyiti o jẹ atẹle pẹlu fibrosis ajeji.Idiwọn idagbasoke ti iyipada (TGF)-β1-induced ni nọmba myofibroblast ṣe ipa pataki ninu fibrosis ajeji yii.Laipẹ a rii pe mepenzolate bromide (mepenzolate), eyiti a ti lo ni ile-iwosan lati ṣe itọju awọn rudurudu ikun-inu, ni awọn ohun-ini idinku ROS.Ninu iwadi ti o wa lọwọlọwọ, a ṣe ayẹwo ipa ti mepenzolate lori bleomycin-induced pulmonary fibrosis ati ailagbara ẹdọfóró ninu awọn eku.Iwọn ti fibrosis ẹdọforo ni a ṣe ayẹwo nipasẹ igbelewọn histopathologic ati ipinnu awọn ipele hydroxyproline.Awọn ẹrọ imọ-ẹrọ ẹdọfóró (elastance) ati iṣẹ atẹgun [agbara pataki ti a fipa mu (FVC)] ni a ṣe ayẹwo nipa lilo ẹrọ atẹgun iṣakoso kọmputa kan.A tun ṣe agbeyẹwo iṣẹ atẹgun nipasẹ ṣiṣe abojuto itẹlọrun atẹgun iṣọn-ẹjẹ percutaneous (SpO2).Isakoso intracheal ti mepenzolate ṣaaju ṣiṣe itọju bleomycin dinku iwọn fibrosis ẹdọforo ati awọn iyipada ninu awọn ẹrọ ẹdọfóró ati yori si imularada pataki ti mejeeji FVC ati SpO2 ni akawe pẹlu iṣakoso.Pẹlupẹlu, mepenzolate ṣe ipa itọju ailera paapaa nigbati o ti nṣakoso lẹhin idagbasoke ti fibrosis.Isakoso ti mepenzolate tun ṣe idiwọ iku sẹẹli ẹdọforo ti o fa bleomycin ati awọn idahun iredodo ati alekun nọmba myofibroblast.Mepenzolate tun dinku iṣẹ NADPH oxidase ati ipele TGF-β1 ti nṣiṣe lọwọ tabi iṣẹ glutathione S-transferase (GST) ti o pọ si ni iwaju itọju bleomycin.Awọn abajade wọnyi fihan pe iṣakoso intracheal ti mepenzolate dinku bleomycin-induced pulmonary fibrosis ati ailagbara ẹdọfóró ninu awọn eku.Awọn ipa wọnyi le jẹ nitori ipa inhibitory oogun yii lori NADPH oxidase ati awọn iṣẹ TGF-β1 ati ipa iyanju rẹ lori GST.
