D-Valine Cas: 640-68-6 C5H11NO2
| Nọmba katalogi | XD90291 |
| Orukọ ọja | D-Valine |
| CAS | 640-68-6 |
| Ilana molikula | C5H11NO2 |
| Òṣuwọn Molikula | 117.14634 |
| Awọn alaye ipamọ | Iwọn otutu yara |
| Ti irẹpọ Owo idiyele koodu | 29224995 |
Ọja Specification
| Ayẹwo | 99% |
| Ifarahan | funfun lulú |
| iwuwo | 1.2000 (iṣiro) |
| Ojuami yo | > 295 °C (sbl.) (tan.) |
| Oju omi farabale | 213.6 °C ni 760 mmHg |
| oju filaṣi | 83℃ |
| Atọka itọka | -27 ° (C=8, 6mol/L HCl) |
| Solubility | 56 g/L (20°C) |
| Omi solubility | 56 g/L (20ºC) |
| PSA | 63.32000 |
| LogP | 0.75460 |
| Yiyi pato | -27.5º (c=5, 5N HCl) |
| Opitika aṣayan iṣẹ-ṣiṣe | [α] 23/D -32.0 si -24.0°, c = 8 ni 6 M HCl |
Awọn obinrin ti o ni iṣọn antiphospholipid (APS) wa ninu eewu ti o pọ si pipadanu oyun loorekoore (RPL) ati preeclampsia.Awọn egboogi Antiphospholipid (aPL) taara paarọ iṣẹ trophoblast.Itoju pẹlu heparin iwuwo molikula kekere (LMWH) dinku eewu RPL ṣugbọn kii ṣe preeclampsia.Pẹlupẹlu, LMWH ṣe iwuri itusilẹ trophoblast sFlt-1, ifosiwewe anti-angiogenic ti o ni nkan ṣe pẹlu preeclampsia.Niwọn igba ti aipe Vitamin D ti ni nkan ṣe pẹlu APS ati preeclampsia, iwadi yii wa lati pinnu ipa ti Vitamin D lori iṣẹ trophoblast ni eto aPL ati LMWH.A human first trimester trophoblast cell line (HTR8) ati awọn aṣa trophoblast akọkọ ni a tọju pẹlu tabi laisi aPL ni wiwa ati isansa ti Vitamin D, LMWH tabi awọn mejeeji.Imudaniloju Trophoblast ti awọn cytokines iredodo ati awọn okunfa angiogenic ni a ṣe iwọn nipasẹ ELISA.Vitamin D nikan tabi ni apapo pẹlu LMWH ṣe atẹgun aPL-induced trophoblast iredodo esi ninu awọn sẹẹli HTR8 ati awọn aṣa akọkọ.Lakoko ti Vitamin D ko ni ipa lori iyipada ti aPL-mediated ti awọn ifosiwewe angiogenic ni trophoblast akọkọ, o ṣe idiwọ LMWH-induced sFlt-1 release.LMWH ni apapo pẹlu Vitamin D le jẹ anfani diẹ sii ju itọju ailera-ọkan lọ nipasẹ idilọwọ aPL -induced trophoblast iredodo ati yiyipada LMWH-induced sFlt-1 yomijade.
