D-Mannitol Cas: 69-65-8 96-101.5% funfun kristali lulú
| Nọmba katalogi | XD90226 |
| Orukọ ọja | D-Mannitol |
| CAS | 69-65-8 |
| Ilana molikula | C6H14O6 |
| Òṣuwọn Molikula | 182.1718 |
| Awọn alaye ipamọ | Ibaramu |
| Ti irẹpọ Owo idiyele koodu | 29054300 |
Ọja Specification
| Ojuami Iyo | 164 - 169 Deg C |
| Ipele | BP |
| Yiyi pato | +23 - +25 |
| AS | <1ppm |
| Isonu lori Gbigbe | <0.3% |
| Sulfate | <0.01% |
| Ayẹwo | 96 - 101.5% |
| Nickel | ≤1pm |
| Acid | <0.2ml |
| Idinku Suga | ≤ 0.1% |
| Iwa ihuwasi | 20us/cm |
| Cl | <0.007% |
| Ifarahan | Funfun okuta lulú |
Lati ṣe iwadii ipa ti aapọn oxidative ati / tabi ailagbara mitochondrial ni iṣẹlẹ ti ọgbẹ kidirin nla (AKI) lakoko sepsis, a ṣe agbekalẹ awoṣe ti o ni in vitro ti a fa sepsis nipa lilo awọn sẹẹli epithelial tubular isunmọ ti o farahan si endotoxin kokoro (lipopolysaccharide, LPS).Iwadii yii ti pese awọn ẹya pataki lori ibatan laarin aapọn oxidative ati awọn abawọn iṣẹ ṣiṣe pq mitochondrial.Itọju LPS yorisi ilosoke ninu ikosile ti inducible nitric oxide synthase (iNOS) ati NADPH oxidase 4 (NOX-4), ni iyanju cytosolic overexpression ti nitric oxide ati superoxide anion, awọn ẹya nitrogen ifaseyin akọkọ (RNS) ati awọn ẹya atẹgun ifaseyin. (ROS).Ipo oxidant yii dabi enipe o da gbigbi phosphorylation oxidative mitochondrial nipa idinku iṣẹ ṣiṣe cytochrome c oxidase.Nitoribẹẹ, awọn idalọwọduro ninu gbigbe elekitironi ati fifa proton kọja awo inu mitochondrial ti inu waye, ti o yori si idinku agbara membran rial mitochond, itusilẹ ti awọn nkan ti nfa apoptotic ati idinku ti triphosphate adenosine.O yanilenu, lẹhin ifọkansi nipasẹ RNS ati ROS, mitochondria di olupilẹṣẹ titan ti ROS, nitorinaa ṣe idasi lati mu ailagbara mitochondrial pọ si.Ipa ti awọn oxidants ni aiṣedeede mitochondrial ni a ti fi idi mulẹ siwaju nipasẹ lilo awọn inhibitors iNOS tabi awọn antioxidants ti o tọju iṣẹ ṣiṣe cytochrome c oxidase ati ṣe idiwọ ipadasẹhin awo-ara mitochondrial.Awọn abajade wọnyi daba pe AKI ti o fa sepsis ko yẹ ki o gba nikan bi ikuna ti ipo agbara ṣugbọn tun bi idahun ti a ṣepọ, pẹlu awọn iṣẹlẹ transcriptional, ifihan ROS, iṣẹ mitochondrial ati iṣalaye iṣelọpọ bi apoptosis.
