5-Sulfosalicylic acid dihydrate Cas: 5965-83-3 Funfun si okuta kristali funfun
| Nọmba katalogi | XD90230 |
| Orukọ ọja | 5-Sulfosalicylic acid dihydrate |
| CAS | 5965-83-3 |
| Ilana molikula | C7H10O8S |
| Òṣuwọn Molikula | 254.215 |
| Awọn alaye ipamọ | Ibaramu |
| Ti irẹpọ Owo idiyele koodu | 29182900 |
Ọja Specification
| Sulfate | ti o pọju 5.5%. |
| Ọrinrin | ti o pọju 22%. |
| Ifarahan | Funfun si pa-funfun gara |
| Apapọ acid | 99 - 104% |
| Ayẹwo | 99% |
Polycations ti wa ni waidi bi awọn aruwo lati fi mba nucleic acids mba.Polycations jẹ inert elegbogi ti aṣa pẹlu iṣẹ-ẹri ti jiṣẹ ẹru itọju ailera.Iwadi yii ṣe ijabọ iṣelọpọ ti polycation ti ara-immolative (DSS-BEN) ti o da lori oogun afọwọṣe polyamine kan N(1), N (11) -bisethylnorspermine (BENSpm).A ṣe apẹrẹ polycation lati ṣiṣẹ ni ilọpo meji bi agbẹru gbigbe jiini ati prodrug ti n fojusi iṣelọpọ polyamine dysregulated ninu akàn.Lilo apapọ NMR ati HPLC, a jẹrisi pe polycation ara-immolative faragba ibajẹ intracellular sinu oogun obi BENSpm.BENSpm ti a ti tu silẹ dinku awọn ipele cellular ti spermidine ati spermine ati ki o ṣe atunṣe polyamine catabolic enzymes spermine / spermidine N (1) -acetyltransferase (SSAT) ati spermine oxidase (SMO).Awọn polycations ti iṣelọpọ ṣe awọn polyplexes pẹlu DNA ati dẹrọ gbigbe daradara.Lilo anfani ti agbara BENSpm lati ṣe akiyesi awọn sẹẹli alakan si TNFa-induced apoptos jẹ, a fihan pe DSS-BEN ṣe alekun iṣẹ ṣiṣe pipa sẹẹli ti itọju jiini TNFa.Awọn awari ti o royin jẹ ifọwọsi DSS-BEN gẹgẹbi eto ifijiṣẹ iṣẹ-meji ti o le ṣe jiini oogun kan ati ilọsiwaju abajade ti itọju ailera pupọ nitori abajade ibajẹ intracellular ti DSS-BEN si BENSpm ati ipa anfani ti o tẹle ti BENSpm lori polyamine dysregulated iṣelọpọ agbara ni akàn.
