Uridine,2′-deoxy-5-ethynyl- Cas:61135-33-9
| Nọmba katalogi | XD90589 |
| Orukọ ọja | Uridine,2'-deoxy-5-ethynyl- |
| CAS | 61135-33-9 |
| Ilana molikula | C11H12N2O5 |
| Òṣuwọn Molikula | 252.23 |
| Awọn alaye ipamọ | -20°C |
| Ti irẹpọ Owo idiyele koodu | 29349990 |
Ọja Specification
| Ifarahan | Funfun to Orange to Green lulú to gara |
| Ayẹwo | ≥99% |
Iwadi yii ni a ṣe lati ṣe iwadii ipa imudara ti awọn peptides soy Ewebe lori awọn sẹẹli agba agba (ASCs) ni laisi omi ara ati awọn ilana iṣe iṣe wọn.Ilọsiwaju ti awọn sẹẹli adipose ti ara eniyan ti o ni iyọdajẹ mesenchymal stem cell (ADSCs) ati okun ti o ni ẹjẹ ti o ni awọn sẹẹli mesenchymal (CB-MSCs) ti a mu pẹlu awọn peptides soy ni a ri lati pọ sii ni pataki lori 3- (4,5-dimethylthiazol-2-yl). -2,5-diphenyltetrazolium bromide ati Click-iT 5-ethynyl-2'-deoxyuridine sisan cytometry.Ni afikun, soy peptides yori si stepwise phosphorylation ti p44/42 MAPK (ERK), mammalian afojusun ti rapamycin (mTOR), p70 S6 kinase, S6 ribosomal protein (S6RP) ati eukaryotic initiation ifosiwewe 4E (eIF4E) ni ADSCs.Pẹlupẹlu, iṣeduro titobi ti awọn cytokines ṣe afihan pe iṣelọpọ ti iyipada idagbasoke-beta1 (TGF-β1), ifosiwewe idagbasoke endothelial ti iṣan ati interleukin-6 pọ si ni pataki ni idahun si itọju pẹlu awọn peptides soy ni awọn ADSCs ati CB-MSC.Bakanna, soy peptide-induced phosphorylation ti ọna ERK/mTOR/S6RP/eIF4E ti dina ni idahun si iṣaaju pẹlu PD98059, oludena ERK kan pato.Pẹlupẹlu, idinamọ ti TGF-β1 nipasẹ PD98059 pretreatment ati idinku itẹlera ni afikun ADSC fihan pe TGF-β1 nfa phosphorylation ti mTOR/S6RP/eIF4E.Lapapọ, awọn abajade iwadi yii fihan pe iṣelọpọ ti o gbẹkẹle ERK ti TGF-β1 ṣe ipa pataki ninu isọdọtun soy peptide-induced ti ADSCs labẹ awọn ipo ti ko ni omi ara. Aṣẹ-lori-ara © 2012 Elsevier Inc. Gbogbo ẹtọ wa ni ipamọ.
