Trimethoprim Cas: 738-70-5
| Nọmba katalogi | XD92385 |
| Orukọ ọja | Trimethoprim |
| CAS | 738-70-5 |
| Molecular Formula | C14H18N4O3 |
| Òṣuwọn Molikula | 290.32 |
| Awọn alaye ipamọ | 2-8°C |
| Ti irẹpọ Owo idiyele koodu | 29335995 |
Ọja Specification
| Ifarahan | A funfun tabi ofeefee-funfun lulú |
| Asay | 99% iṣẹju |
| Ojuami Iyo | 199 - 203 Deg C |
| Awọn irin ti o wuwo | ≤20ppm |
| Isonu lori Gbigbe | ≤1.0% |
| Awọn nkan ti o jọmọ | ≤0.2% |
| Solubility | Gidigidi die-die tiotuka ninu omi, die-die tiotuka ninu oti, Oba insoluble ni ether |
Trimethoprim jẹ lipophilic ati alailagbara ipilẹ pyrimethamine aṣoju bacteriostatic kilasi.O jẹ funfun tabi fere funfun lulú kristali, odorless, kikorò, ati die-die tiotuka ni chloroform, ethanol tabi ati acetone, sugbon fere insoluble ninu omi ati ki o nyara tiotuka ni glacial acetic acid ojutu.O ni spekitiriumu antibacterial eyiti o jọra pẹlu awọn oogun sulfa, ṣugbọn pẹlu ipa antibacterial to lagbara.O ni ipa ti o dara lori itọju Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Staphylococcus saprophyticus, ati ọpọlọpọ awọn kokoro arun ti o ni giramu-rere ati odi.Ṣugbọn ko ni doko lodi si ikolu Pseudomonas aeruginosa.Idojukọ inhibitory ti o kere ju nigbagbogbo jẹ kere ju 10 miligiramu / L pẹlu lilo nikan ni irọrun lati fa idiwọ kokoro-arun, ati nitorinaa a ko lo ni gbogbogbo nikan, ati ni apapọ pẹlu oogun sulfa lati dagba igbaradi agbo fun itọju ile-iwosan ti awọn akoran ito, ifun. àkóràn, àkóràn atẹgun, dysentery, enteritis, typhoid iba, meningitis, otitis media, meningitis, sepsis ati awọn àkóràn àsopọ rirọ.O ni ipa lori atọju typhoid ati ipa paratyphoid eyiti ko kere ju ampicillin;O tun le ni idapo pelu awọn oogun sulfa ti o gun fun idena ati itọju iba falciparum ti ko ni oogun.
Ilana ipilẹ ti egboogi-kokoro ti trimethoprim ni lati dabaru pẹlu iṣelọpọ folate ni awọn kokoro arun.Ilana akọkọ ti iṣe ni idinamọ yiyan iṣẹ ṣiṣe ti dihydrofolate reductase ninu awọn kokoro arun ki dihydrofolate ko le dinku si tetrahydrofolate.Niwọn igba ti iṣelọpọ ti folic acid jẹ apakan akọkọ ti biosynthesis acid nucleic, ati nitori naa ọja ṣe idiwọ awọn acids nucleic kokoro-arun ati iṣelọpọ awọn ọlọjẹ.Pẹlupẹlu, ifaramọ ti trimethoprim (TMP) si kokoro-arun dihydrofolate reductase henensiamu jẹ igba marun ni agbara bi iyẹn si mammalian dihydrofolate reductase.Apapo laarin rẹ pẹlu awọn oogun sulfa le fa idena meji si folic acid biosynthesis ti iṣelọpọ agbara ti awọn kokoro arun ki ipa synergistic kan wa eyiti yoo jẹki iṣẹ ṣiṣe antibacterial ti awọn oogun sulfa, ati pe o le tan ipa antibacterial si ipa bactericidal eyiti o dinku sooro oogun. awọn igara.Ni afikun, ọja naa tun le mu awọn ipa antibacterial ti ọpọlọpọ awọn egboogi miiran (gẹgẹbi tetracycline, gentamicin).
