Spiramycin Cas: 8025-81-8
| Nọmba katalogi | XD90452 |
| Orukọ ọja | Spiramycin |
| CAS | 8025-81-8 |
| Ilana molikula | C43H74N2O14 |
| Òṣuwọn Molikula | 843.05 |
| Awọn alaye ipamọ | 2 si 8 °C |
| Ti irẹpọ Owo idiyele koodu | 29419000 |
Ọja Specification
| Ifarahan | Funfun Powder |
| Ayẹwo | > 4100IU/mg |
| Awọn irin ti o wuwo | <20ppm |
| Isonu lori Gbigbe | <3.5% |
| Sulfated Ash | <1.0% |
| Ethanol | <2.0% |
| Yiyi opitika pato | -85 to -80 iwọn |
Streptomyces ambofaciens ṣe akopọ spiramycin aporo aporo macrolide.Awọn iṣupọ jiini biosynthetic fun spiramycin ti jẹ ifihan fun S. ambofaciens.Ni afikun si jiini ilana srmR (srm22), ti a ti mọ tẹlẹ (M. Geistlich et al., Mol. Microbiol. 6:2019-2029, 1992), awọn jiini ilana putative mẹta ti jẹ idanimọ nipasẹ itupalẹ lẹsẹsẹ.Ṣiṣayẹwo ikosile Gene ati awọn adanwo aiṣiṣẹ jiini fihan pe ọkan ninu awọn Jiini mẹta wọnyi, srm40, ṣe ipa pataki ninu ilana ilana biosynthesis spiramycin.Idalọwọduro ti srm22 tabi srm40 yọkuro iṣelọpọ spiramycin lakoko ti iwọn apọju wọn pọ si iṣelọpọ spiramycin.Atupalẹ ikosile ni a ṣe nipasẹ transcription-PCR (RT-PCR) fun gbogbo awọn jiini ti iṣupọ ninu igara iru-igi ati ninu srm22 (srmR) ati awọn iyipada piparẹ srm40.Awọn abajade lati inu itupalẹ ikosile, pẹlu awọn ti o wa lati awọn adanwo imudara, tọka si pe Srm22 ni a nilo fun ikosile srm40, Srm40 jẹ amuṣiṣẹ-ọna kan pato ti o ṣakoso pupọ julọ, ti kii ba ṣe gbogbo rẹ, ti awọn jiini biosynthetic spiramycin.
