Awọn ọja

S- (+) - Methyl- (2-chlorophenyl) [(2- (2-thienyl) amino] acetate hydrochloride, ti a tun mọ ni S- (+) -Clopidogrel, jẹ ohun elo elegbogi pẹlu ilana kemikali ti C16H16ClNO2SH · HCl. O jẹ itọsẹ chiral ti clopidogrel, eyiti o jẹ oogun antiplatelet pataki kan.Lilo akọkọ ti S- (+) -Methyl- (2-chlorophenyl) [(2- (2-thienyl) amino] acetate hydrochloride jẹ bi ohun ti nṣiṣe lọwọ. eroja ti o wa ninu iṣelọpọ ti awọn oogun inu ọkan ati ẹjẹ, awọn aṣoju antiplatelet pataki, o ṣe awọn ipa itọju ailera rẹ nipasẹ didaduro akojọpọ platelet, idilọwọ dida didi ẹjẹ, ati idinku eewu awọn iṣẹlẹ inu ọkan ati ẹjẹ. ipa pataki ninu imuṣiṣẹ ati akojọpọ awọn platelets Nipa isodi aibikita si olugba yii, S-(+)-Methyl- (2-chlorophenyl) [(2--thienyl) amino] acetate hydrochloride ṣe idiwọ imuṣiṣẹ platelet ati ṣe idiwọ didasilẹ Ipo iṣe iṣe yii jẹ ki o jẹ oogun pataki fun idilọwọ awọn iṣẹlẹ thrombotic ninu awọn alaisan ti o ni eewu giga, gẹgẹbi awọn ti o ni itan-akọọlẹ ti iṣọn-ẹjẹ iṣọn-alọ ọkan nla, ọpọlọ ischemic, tabi arun iṣọn agbeegbe.S- (+)-Methyl- (2-chlorophenyl) [(2- (2-thienyl) amino] acetate hydrochloride ni a maa nṣakoso ni ẹnu ni irisi awọn tabulẹti tabi awọn capsules.Lẹhin jijẹ, o faragba iyipada ti iṣelọpọ ninu ẹdọ lati ṣe ipilẹṣẹ metabolite ti nṣiṣe lọwọ.Metabolite ti nṣiṣe lọwọ sopọ ni aibikita si olugba P2Y12, ni ṣiṣe awọn ipa antiplatelet rẹ fun iye akoko gigun.Apọpọ naa jẹ oogun ni igbagbogbo ni ẹẹkan lojoojumọ, boya bi itọju aiṣoṣo tabi ni apapọ pẹlu awọn oogun antiplatelet miiran, gẹgẹbi aspirin. -thienyl) amino] acetate hydrochloride yẹ ki o ṣee lo nikan labẹ itọsọna ti alamọdaju ilera, nitori lilo rẹ le ni agbara.