Nicotinamide Riboside Cas: 1341-23-7
| Nọmba katalogi | XD91951 |
| Orukọ ọja | Nicotinamide Riboside |
| CAS | 1341-23-7 |
| Molecular Formula | C11H15N2O5+ |
| Òṣuwọn Molikula | 255.25 |
| Awọn alaye ipamọ | Ibaramu |
| Ti irẹpọ Owo idiyele koodu | 2933199090 |
Ọja Specification
| Ifarahan | funfun lulú |
| Asay | 99% iṣẹju |
Nicotinamide Riboside ni a le lo ninu iwadi ti ẹkọ ti ara ti jiini circadian reprogramming transcriptome ninu ẹdọ ṣe idanimọ awọn ipa ọna ijẹ-ara ti ogbo ni Asin.O tun mu NAD + pọ si ni kotesi cerebral ati dinku ibajẹ imọ ni awoṣe asin transgenic ti arun Alzheimer.
Nicotinamide adenine dinucleotide (NAD +) jẹ coenzyme to ṣe pataki ti, nigbati o ba dinku si NADH, ṣe iranṣẹ bi oluranlowo idinku lati ṣetọrẹ awọn elekitironi fun phosphorylation oxidative ati iṣelọpọ ATP ni mitochondria.NAD + jẹ olupilẹṣẹ pataki fun awọn enzymu bii sirtuins, ADP-ribosyltransferases (ARTs), ati Poly [ADP-ribose] polymerases (PARPs) ati pe o jẹ nigbagbogbo nipasẹ awọn ensaemusi wọnyi.Ipin NAD+/NADH jẹ paati pataki ti ipo atunṣe ti sẹẹli naa.(Verdin 2015).Nipa awọn iṣiro diẹ, NAD tabi NADP ti o ni ibatan ṣe alabapin ninu idamẹrin gbogbo awọn aati cellular (Opitz Heiland 2015).Awọn ipin lọtọ ti NAD + wa ninu arin, mitochondria, ati cytoplasm (Verdin 2015).
Nicotinamide riboside (NR) le ṣe iyipada si NAD + nipasẹ igbesẹ agbedemeji eyiti o ti yipada si nicotinamide mononucleotide (NMN) nipasẹ NR kinase (Nrk) ati lẹhinna si NAD + nipasẹ NMNATs.NR jẹ nipa ti ara ni diẹ ninu awọn ounjẹ ṣugbọn ni awọn iwọn kekere pupọ (fun apẹẹrẹ iwọn micromolar kekere).Itan-akọọlẹ, NR nira lati gba ni awọn iye mimọ nla, ṣugbọn o ṣeun si awọn ilọsiwaju ninu awọn ọna iṣelọpọ (Yang 2007), bi Oṣu Karun ọdun 2013, o ta bi afikun ijẹẹmu.
