Iodonitrotetrazolium kiloraidi CAS: 146-68-9
| Nọmba katalogi | XD90473 |
| Orukọ ọja | Iodonitrotetrazolium kiloraidi |
| CAS | 146-68-9 |
| Ilana molikula | C19H13ClIN5O2 |
| Òṣuwọn Molikula | 505.70 |
| Awọn alaye ipamọ | 2 si 8 °C |
| Ti irẹpọ Owo idiyele koodu | 32129000 |
Ọja Specification
| Idanimọ | H-NMR |
| Ifarahan | Ina ofeefee to osan lulú |
| Ayẹwo | > 99% |
| Solubility | Ko ojutu |
Interferon-induced transmembrane protein 1 (IFITM1) jẹ ọkan ninu awọn ọmọ ẹgbẹ ẹbi amuaradagba transmembrane ti o fa interferon.Ninu iwadi yii, a royin pe ikosile IFITM1 ti o ga ni akàn colorectal eniyan (CRC) ni ibamu pataki pẹlu CRC lymph node ati metastasis ijinna bi daradara bi ipele ile-iwosan ti ilọsiwaju diẹ sii.Ni pataki, ikosile IFITM1 ti o ga jẹ ifosiwewe asọtẹlẹ ominira fun iwalaaye talaka.Lati ṣe iwadii awọn ilana molikula, a fihan pe ikosile pupọ ti IFITM1 ninu awọn sẹẹli CRC ni igbega, lakoko ti ikọlu ti ikosile IFITM1 ti ni idinamọ, iṣipopada sẹẹli / ayabo ati tumorigenicity in vitro.Pẹlupẹlu, a ṣe idanimọ Caveolin-1 (CAV1) gẹgẹbi ibi-afẹde ti o wa ni isalẹ ti IFITM1-induced cell invasion, bi knockdown ti CAV1 fagilee siIFITM1 mediated inhibition of cell invasion in CRC cells.Ni afikun, ninu ẹgbẹ CRC ti awọn alaisan 229, ikosile ti IFITM1 ni ibamu pẹlu ikosile ti CAV1.Awọn abajade wọnyi daba pe IFITM1 ṣe agbega aggr essiveness ti awọn sẹẹli CRC, ati pe o jẹ ami isọtẹlẹ ti o pọju ati ibi-afẹde itọju fun CRC.
