Awọn ọja

Ọpọlọpọ awọn analogues guanosine, ie acyclovir (ati prodrug oral valaciclovir), penciclovir (ninu fọọmu prodrug ẹnu rẹ, famciclovir) ati ganciclovir, ni lilo pupọ fun itọju herpesvirus [ie Herpes simplex virus type 1 (HSV-1), ati iru 2 (HSV-2), varicella-zoster virus (VZV) ati/tabi eda eniyan cytomegalovirus (HCMV)] àkóràn.Ni awọn ọdun aipẹ, ọpọlọpọ awọn analogues guanosine tuntun ti ni idagbasoke, pẹlu 3-membered cyclopropylmethyl ati -methenyl itọsẹ (A-5021 ati synguanol) ati 6-membered D- ati L-cyclohexenyl itọsẹ.Iṣẹ ṣiṣe ti acyclic/carbocyclic guanosine analogues ti pinnu lodi si ọpọlọpọ awọn ọlọjẹ, pẹlu HSV-1, HSV-2, VZV, HCMV, ati paapaa awọn ọlọjẹ herpes eniyan iru 6 (HHV-6), iru 7 (HHV- 7) ati iru 8 (HHV-8), ati arun jedojedo B (HBV).Awọn analogues guanosine tuntun (ie A-5021 ati D- ati L-cyclohexenyl G) ni a rii pe o ṣiṣẹ ni pataki si awọn ọlọjẹ wọnyẹn (HSV-1, HSV-2, VZV) ti o koodu fun thymidine kinase kan pato (TK), ni iyanju pe iṣẹ ṣiṣe antiviral wọn (o kere ju apakan) da lori phosphorylation nipasẹ TK ti o fa ọlọjẹ naa.Iṣẹ ṣiṣe antiviral ti a samisi ni a tun ṣe akiyesi pẹlu A-5021 lodi si HHV-6 ati pẹlu D- ati L-cyclohexenyl G lodi si HCMV ati HBV.Iṣẹ-ṣiṣe antiviral ti awọn analogues acyclic/carbocyclic nucleoside le jẹ agbara ti o ṣe pataki nipasẹ mycophenolic acid, oludena ti o lagbara ti inosine 5'-monophosphate (IMP) dehydrogenase.Awọn analogues carbocyclic guanosine tuntun (ie A-5021 ati D- ati L-cyclohexenyl G) ṣe ileri nla, kii ṣe bi awọn aṣoju antiviral nikan fun itọju awọn akoran ti herpesvirus, ṣugbọn awọn aṣoju antitumor fun apapọ itọju ailera / chemotherapy ti akàn, pese pe (apakan ti) awọn sẹẹli tumo ti ni iyipada nipasẹ gbogun ti (HSV-1, VZV) TK pupọ.