Glutathione dinku Cas: 70-18-8 98-101% Ko o ati awọ
| Nọmba katalogi | XD90284 |
| Orukọ ọja | Glutathione dinku |
| CAS | 70-18-8 |
| Ilana molikula | C10H17N3O6S |
| Òṣuwọn Molikula | 307.32 |
| Awọn alaye ipamọ | 2 si 8 °C |
| Ti irẹpọ Owo idiyele koodu | 29309098 |
Ọja Specification
| Ayẹwo | 98% - 101% |
| Ifarahan | Funfun okuta lulú |
| Ipele | EP 7.0 |
| Aimọ́ A | <0.5% |
| Aimọ́ B | <0.5% |
| Awọn irin ti o wuwo | <10ppm |
| Endotoxin kokoro arun | <0.10EU/mg |
| Iwa aimọ C | <1.5% |
| Àìmọ́ D | <1.0% |
| Isonu lori Gbigbe | <0.5% |
| Solubility | Tiotuka larọwọto ninu omi, die-die tiotuka ninu ethanol ati methylene kiloraidi |
| Irin | <10ppm |
| Klorides | <200ppm |
| Ifarahan ti Solusan | Ko o ati awọ |
| Yiyi opitika pato | -15.5 to -17.5 |
| Lapapọ Awọn Aimọ | <2.5% |
| Ammonium | <200ppm |
| eeru sulfated | <0.1% |
| Sulfates | <300ppm |
| Aimọ́ E | <0.5% |
Awọn iyipada amuaradagba lẹhin-itumọ, gẹgẹbi phosphorylation tyrosine, ṣe ilana awọn ibaraẹnisọrọ amuaradagba-amuaradagba (PPI) pataki fun sisẹ ifihan ati awọn phenotypes cellular.A gbooro eto iwukara meji-arabara ti iṣeto ti n gba awọn kinases amuaradagba eniyan fun awọn itupalẹ ti phospho-tyrosine (pY) ti o gbẹkẹle PPI ni idanwo taara, ọna iwọn-nla.A ṣe idanimọ 292 pupọ julọ aramada pY-ti o gbẹkẹle PPI eyiti o ṣe afihan iyasọtọ giga pẹlu ọwọ si awọn kinases ati awọn ọlọjẹ ibaraenisepo ati pe o jẹri ida nla kan ninu awọn adanwo ijẹẹmu ajẹsara lati awọn sẹẹli mammalian.O fẹrẹ to idamẹfa ti awọn ibaraenisepo jẹ ilaja nipasẹ awọn ilana isọdọmọ lẹsẹsẹ laini ti a mọ lakoko ti ọpọlọpọ awọn pY-PPI jẹ olulaja nipasẹ awọn epitopes laini miiran tabi iṣakoso nipasẹ awọn ipo idanimọ yiyan.Onínọmbà nẹtiwọọki ṣe afihan pe awọn iṣẹlẹ idanimọ ti o ni agbedemeji pY ni a so mọ module amuaradagba ti o ni asopọ giga ti a ṣe igbẹhin si ami ifihan ati awọn ipa ọna idagbasoke sẹẹli ti o ni ibatan si akàn.Lilo awọn igbelewọn abuda, amuaradagba pari orilẹ-ede ati awọn iwe kika phenotypic lati ṣe apejuwe awọn ibaraenisepo ti o gbẹkẹle pY ti TSPAN2 (tetraspanin 2) ati GRB2 tabi PIK3R3 (p55γ), a ṣe apẹẹrẹ ni apẹẹrẹ pe awọn PPI ti o gbẹkẹle pY meji n ṣalaye awọn aarun alakan cellular.
