DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) CAS: 28718-90-3 99% Iyẹfun Yellow
| Nọmba katalogi | XD90505 |
| Orukọ ọja | DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) |
| CAS | 28718-90-3 |
| Ilana molikula | C16H15N5 · 2HCl |
| Òṣuwọn Molikula | 350.25 |
| Awọn alaye ipamọ | Ibaramu |
| Ti irẹpọ Owo idiyele koodu | 2933998090 |
Ọja Specification
| Ifarahan | Iyẹfun ofeefee |
| Ayẹwo | 99% iṣẹju |
| Fun lilo iwadi nikan, kii ṣe fun lilo eniyan | Lilo iwadi nikan, kii ṣe fun lilo eniyan |
Melatonin ni ipa ninu ọpọlọpọ awọn iṣẹ iṣe-ara, ati pe o ni awọn ipa iyatọ lori apoptosis ni deede ati awọn sẹẹli alakan.Sibẹsibẹ, ilana ti awọn ipa antitumor rẹ ko ni oye daradara.Ninu iwadi yii, a fihan pe melatonin nmu apoptosis ti o ni itọsi tunicamycin ninu awọn sẹẹli igbaya igbaya eniyan MDA-MB-231.Melatonin soke-ṣe iṣakoso pro-apoptotic amuaradagba Bim ikosile ni awọn ipele transcriptional niwaju tunicamycin.Melatonin ṣe idiwọ ikosile COX-2 ti tunicamycin ninu awọn sẹẹli MDA-MB-231.Pẹlupẹlu, idinamọ ti iṣẹ-ṣiṣe COX-2 nipa lilo oludena COX-2, NS398, mu apoptosis ti o fa tunicamycin.O yanilenu, awọn ipa wọnyi ko ni nkan ṣe pẹlu awọn ipa ọna ifihan agbara olugba melatonin.Majele Pertussis (oludana amuaradagba Gi gbogbogbo) tabi luzindole (antagonist olugba olugba melatonin kan) ko yi ipa ti melatonin pada.Ni afikun, melatonin dina tunicamycin-induced NF-κB transcriptional aṣayan iṣẹ-ṣiṣe, p65 iparun translocation, ati p38 MAPK igbese ivation.Melatonin-mediated p38 MAPK idinamọ ṣe alabapin si idinku iduroṣinṣin COX-2 mRNA.Papọ, awọn abajade wa daba pe melatonin mu iṣẹ antitumor pọ si nipasẹ ilana-ila ti ikosile Bim ati ilana-isalẹ ti ikosile COX-2 ni awọn sẹẹli MDA-MB-231 tunicamycin ti a tọju.
