4-Amino-1- ((2R,4S,5R) -4-hydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyrimidin-2 (1H) -ọkan Cas: 951-77-9
| Nọmba Katalogi: | XD90580 |
| Cas: | 951-77-9 |
| Fọọmu Molecular: | C9H13N3O4 |
| Ìwọ̀n Molikula: | 227.22 |
| Wiwa: | O wa |
| Iye: | |
| Iṣakojọpọ: | 1g USD10 |
| Apo Ọpọ: | Beere Quote |
Ọja Specification
| Ifarahan | Funfun okuta lulú |
| Ayẹwo | 99% |
| Ojuami Iyo | 196°C - 200°C |
Thymidine phosphorylase (TP, EC 2.4.2.4) mọ ilana ti sobusitireti pẹlu iyasọtọ giga, nipasẹ mejeeji ipilẹ ati awọn ẹya ribosyl.Rirọpo 3'-OH ti thymidine ṣe pataki ni ipa lori iṣẹ ṣiṣe catalytic rẹ pẹlu TP.Iyipada ti awọn nucleosides pyrimidine pẹlu awọn ipilẹ ipilẹ ti a ṣe atunṣe si fọọmu 1-fosifeti ti o baamu ko dara.Iṣẹ-ṣiṣe ẹgbẹ ti o lọ silẹ dinku pẹlu ilosoke ninu aromaticity ti ipilẹ pyrimidine, nitori iṣoro ti o pọ si ni polarizing ipilẹ nipasẹ awọn amino acids agbegbe si aaye ti nṣiṣe lọwọ.Rirọpo awọn ẹgbẹ iṣẹ-ṣiṣe 3' ati 5' fẹ lati dinku oṣuwọn ifaseyin ati iyipada ogorun pẹlu TP.Ni pataki ẹgbẹ ribosyl 3' hydroxyl jẹ pataki igbekale ipilẹ fun dipọ sobusitireti nipasẹ henensiamu.Ayẹwo kainetik ṣe afihan ni kedere K(m) giga ati awọn iye V (max) kekere lori rirọpo ẹgbẹ 3' hydroxyl pẹlu hydrogen.
