Uridine-5′-diphosphoglucuronic acid trisodium iyọ CAS: 63700-19-6 Funfun lulú
| Nọmba katalogi | XD90382 |
| Orukọ ọja | Uridine-5'-diphosphoglucuronic acid trisodium iyọ |
| CAS | 63700-19-6 |
| Ilana molikula | C15H19N2O18P2Na3 |
| Òṣuwọn Molikula | 646.20 |
| Awọn alaye ipamọ | <-4°C |
Ọja Specification
| Ayẹwo | 99% |
| Ifarahan | funfun lulú |
Iwadi lọwọlọwọ ni ero lati ṣe iwadii ipa ti majele ti irinotecan nipasẹ biotransformation ti glucoaurantio-obtusin si aurantio-obtusin.Isakoso intraperitoneal (ip) ti 100 mg/kg aurantio-obtusin ṣe alekun majele ti irinotecan, ṣugbọn iṣakoso ip ti 100 mg/kg glucoaurantio-obtusin ṣe afihan ipa aifiyesi si majele ti irinotecan.Pẹlupẹlu, a ṣe alaye ẹrọ naa nipasẹ ṣiṣe ipinnu agbara idinamọ ti glucoaurantio-obtusin ati aurantio-obtusin si ọna iṣelọpọ glucuronidation ti SN-38 ti o jẹ ọja pataki ti nṣiṣe lọwọ lodidi fun majele ti irinotecan.Awọn abajade fihan pe aurantio-obtusin ṣe afihan idinamọ ifigagbaga ti o lagbara si ọna glucuronidation ti SN-38, ṣugbọn agbara idinamọ aibikita ti glucoaurantio-obtusin si ọna SN-38 glucuronidation ni a ṣe akiyesi.Awọn abajade wọnyi fihan pe biotransformation ti glucoaurantio-obtusin si ọna aurantio-obtusin ṣe alekun majele ti irinotecan nipasẹ idinamọ ti SN-38 glucuronidation.
