Tiamulin 98% Cas: 125-65-5
| Nọmba katalogi | XD91893 |
| Orukọ ọja | Tiamulin 98% |
| CAS | 125-65-5 |
| Molecular Formula | C22H34O5 |
| Òṣuwọn Molikula | 378.5 |
| Awọn alaye ipamọ | -20°C |
| Ti irẹpọ Owo idiyele koodu | 2918199090 |
Ọja Specification
| Ifarahan | funfun lulú |
| Asay | 99% iṣẹju |
| Ojuami yo | 170-1710C |
| alfa | D24 +20° (c = 3 ninu abs ethanol) |
| Oju omi farabale | 482.8± 45.0 °C(Asọtẹlẹ) |
| iwuwo | 1.15± 0.1 g/cm3(Asọtẹlẹ) |
| solubility | DMSO:> 10mg/ml (gbona) |
| pka | 12.91± 0.10 (Asọtẹlẹ) |
| opitika aṣayan iṣẹ-ṣiṣe | [α]/D +30 si +40° (c=1; CH2Cl2) |
Pleuromutilin jẹ diterpene ti a ṣe nipasẹ ọpọlọpọ awọn eya ti baidomycete, paapaa iwin Pleurotus, ti a ṣe awari ni ọdun 1951. Pleuromutilin jẹ oogun aporo ti o lagbara ati yiyan pupọ ti o ṣiṣẹ lodi si ọpọlọpọ awọn kokoro arun rere Giramu, laisi idiwọ agbelebu si awọn kilasi apakokoro ti o wa tẹlẹ nitori ipo alailẹgbẹ rẹ. ti igbese.Pleuromutilin ṣe idiwọ iṣelọpọ amuaradagba nipasẹ didimu si agbegbe V ti 23S rRNA ati pe eyi ti yori si idagbasoke ọpọlọpọ awọn afọwọṣe ologbele-synthetic gẹgẹbi awọn ajẹsara iran titun, gẹgẹbi tiamulin ati retapamulin.
Pleuromutilins gẹgẹbi tiamulin ati valnemulin ni a ti lo fun igba diẹ ninu oogun ti ogbo lati tọju awọn akoran elede.Laipẹ diẹ ẹ sii kan pleuromutilin semisynthetic, retapamulin, ti ṣe afihan bi itọju agbegbe fun awọn akoran ti o dara Giramu ninu eniyan.Pleuromutilins ṣe idiwọ iṣẹ-ṣiṣe peptidyl transferase ti ipin ribosomal ti kokoro 50S nipa sisọmọ si aaye A.
