N- (2-Acetamide) iminodiacetic acid Cas: 26239-55-4 99% Funfun lulú
| Nọmba katalogi | XD90194 |
| Orukọ ọja | ADA (N-(-2-Acetamido)iminodiacetic acid) |
| CAS | 26239-55-4 |
| Ilana molikula | C6H10N2O5 |
| Òṣuwọn Molikula | 190.15 |
| Awọn alaye ipamọ | Ibaramu |
| Ti irẹpọ Owo idiyele koodu | 29241900 |
Ọja Specification
| Fe | <5ppm |
| Pb | <5ppm |
| Isonu lori Gbigbe | <0.5% |
| eeru sulfated | <0.1% |
| Ifarahan | funfun lulú |
| Miiran Solvents | Ko si |
| Akoko Ituka (9g ninu 91ml 1M NaOH, Aruwo oofa) | <1 iseju |
| A300 (9% ni 1 M NaOH) | <0.08% |
| Nọmba awọn aaye ipari Ti a ṣe akiyesi ni ọna titration | Meji nikan |
| Iwọn pH ti o ṣe asọye Titration Ipari Ipari Keji | 9.1 - 10.1 |
| Solubility (9% ni 1M NaOH) | Ko o ati Awọ |
| Ọjọ iṣelọpọ | |
| Omi KF | <1% |
| Assay (Titration) lori ipilẹ ti o gbẹ | > 99.0% |
| Infurarẹẹdi | Ibamu |
Adenosine nucleoside n ṣiṣẹ lori aifọkanbalẹ ati awọn eto inu ọkan ati ẹjẹ nipasẹ olugba A2A (A2AR).Ni idahun si ipele atẹgun ninu awọn tisọ, ifọkansi pilasima adenosine jẹ ofin ni pataki nipasẹ iṣelọpọ rẹ nipasẹ CD73 ati nipasẹ ibajẹ rẹ nipasẹ adenosine deaminase (ADA).Endopeptidase CD26 ti o dada sẹẹli n ṣakoso ifọkansi ti vasoactive ati awọn peptides antioxidant ati nitorinaa ṣe ilana ipese atẹgun si awọn ara ati idahun aapọn oxidative.Botilẹjẹpe apọju ti adenosine, CD73, ADA, A2AR, ati CD26 ni idahun si hypoxia jẹ akọsilẹ daradara, awọn ipa ti hyperoxic ati awọn ipo hyperbaric lori awọn eroja wọnyi yẹ akiyesi siwaju sii.Awọn eku ati laini sẹẹli Chem-3 murine kan ti o ṣalaye A2AR ti farahan si 0.21 bar O2, 0.79 bar N2 (awọn ipo ori ilẹ; normoxia);1 igi O2 (hyperoxia);2 bar O2 (hyperbaric hyperoxia);0.21 igi O2, 1.79 bar N2 (hyperbaria).Ifojusi pilasima Adenosine, CD73, ADA, A2AR ikosile, ati iṣẹ CD26 ni a koju ni vivo, ati pe iṣelọpọ cAMP ni a koju ni cellulo.Fun awọn ipo vivo, 1) hyperoxia dinku ipele pilasima adenosine ati iṣẹ T cell dada CD26, lakoko ti o pọ si ikosile CD73 ati ipele ADA;2) hyperbaric hyperoxia ti fẹ lati mu aṣa naa pọ si;ati 3) hyperbaria nikan ko ni ipa pataki lori awọn aye wọnyi.Ninu ọpọlọ ati ni cellulo, 1) hyperoxia dinku ikosile A2AR;2) hyperbaric hyperoxia ṣe afikun aṣa naa;ati 3) hyperbaria nikan ṣe afihan ipa ti o lagbara julọ.A rii apẹẹrẹ ti o jọra nipa iṣelọpọ A2AR mRNA mejeeji ninu ọpọlọ ati iṣelọpọ CAMP ni awọn sẹẹli Chem-3.Nitorinaa ipele atẹgun ti o ga julọ fẹ lati dinku ọna adenosinergic ati iṣẹ CD26.Hyperbaria nikan ni o kan ikosile A2AR nikan ati iṣelọpọ cAMP.A jiroro bi iru awọn ọna ṣiṣe ti nfa nipasẹ hyperoxygenation le ṣe opin, nipasẹ vasoconstriction, ipese atẹgun si awọn tissu ati iṣelọpọ awọn eya atẹgun ifaseyin.
