Awọn ọja

Awọn ile-iṣẹ europium (III) ati terbium (III), eyun [Eu (dpq) (DMF) 2 (NO3) 3] (1), [Eu (dppz) 2 (NO3) 3] (2), [Tb (dpq) (DMF) 2Cl3] (3), ati [Tb (dppz) (DMF) 2Cl3] (4), nibiti dipyrido [3,2-d: 2',3'-f] quinoxaline (dpq ninu 1 ati 3) , dipyrido [3,2-a: 2',3'-c] phenazine (dppz ni 2 ati 4) ati N, N'-dimethylformamide (DMF) ti ya sọtọ, ti a ṣe afihan lati inu data physicochemical wọn, awọn ẹkọ luminescence ati ibaraenisepo wọn. pẹlu DNA, serum albumin amuaradagba ati Fọto-induced DNA cleavage aṣayan iṣẹ-ṣiṣe ti wa ni iwadi.Awọn ẹya kristali X-ray ti awọn eka 1-4 ṣe afihan awọn ipilẹ mononuclear Ln(3+) ọtọtọ.Eu (3+) ni [Eu (dpq) (DMF) 2 (NO3) 3] (1) ati [Eu (dppz) 2 (NO3) 3] (2) bi [Eu (dppz) 2(NO3) 3 ] · dppz (2a) gba eto dodecahedron bicapped ti o ni idapọ mẹwa pẹlu bidentate N, N-oluranlọwọ dpq ligand, DMF meji ati mẹta NO3 (-) anions ni 1 ati meji bidentate N, N-oluranlọwọ dppz ligands ati mẹta NO3 ( -) awọn anions ni 2. Awọn eka 3 ati 4 ṣe afihan eto iṣọpọ mono-capped octahedron meje nibiti Tb (3+) ni awọn ligands bidentate dpq/dppz, DMF meji ati awọn anions Cl (-) mẹta.Awọn eka naa jẹ luminescent ti o ga ni iseda ti n tọka gbigbe gbigbe-yiya fọto daradara lati eriali dpq/dppz si Ln(3+) lati ṣe agbekalẹ awọn ipinlẹ itujade itujade gigun fun iwa f → f awọn iyipada.Awọn iwoye luminescence ti akoko-ipinnu ti awọn eka 1-4 ṣe afihan awọn ẹgbẹ itujade ti o jẹ aṣoju ti (5) D0 → (7) F (J) ati (5) D4 → (7) F (J) ff awọn iyipada ti Eu (3) +) ati Tb (3+) ions lẹsẹsẹ.Nọmba awọn ohun elo omi inu inu (q) ni ipinnu lati awọn wiwọn igbesi aye luminescence ni H2O ati D2O ifẹsẹmulẹ awọn aati-paṣipaarọ ligand pẹlu omi ni ojutu.Awọn eka naa ṣe afihan ifaramọ abuda pataki si CT-DNA fifun ni awọn iye abuda igbagbogbo ni sakani 1.0 × 10 (4) -6.1 × 10 (4) M (-1) ni aṣẹ 2, 4 (dppz)> 1, 3 (dpq).Data abuda DNA daba DNA groove abuda pẹlu ipin intercalation iseda ti awọn eka.Gbogbo awọn eka naa tun ṣe afihan ifaramọ abuda (K(BSA) ~ 10(5) M (-1)) si amuaradagba omi ara bovine albumin (BSA).Awọn kikankikan ti awọn akoko-gated luminescence spectral bands mu dara ni pataki pẹlu ifọkansi DNA ti o pọ si ni agbedemeji olomi olomi nitori gbigbe omi ti a so mọ lori ibaraenisepo pẹlu DNA, nitorinaa idinku idinku ti kii ṣe ipanilara nipasẹ oscillator OH.Complexes 1-4 daradara cleave supercoiled (SC) ds-DNA si re nicked ipin (NC) fọọmu lori ifihan si UV-A ina ti 365 nm nipasẹ Ibiyi ti singlet atẹgun ((1) O2) ati hydroxyl radicals (HO˙) bi Ẹya atẹgun ti n ṣe ifọkansi ni awọn ifọkansi micromolar labẹ awọn ipo iṣe-iṣe.