Hoechst 33258 Cas: 23491-45-4 Pale yellow crystalline powder
Nọmba katalogi | XD90536 |
Orukọ ọja | Ọdun 33258 |
CAS | 23491-45-4 |
Ilana molikula | C25H24N6O·3(HCl) |
Òṣuwọn Molikula | 533.88 |
Awọn alaye ipamọ | -15 si -20 °C |
Ti irẹpọ Owo idiyele koodu | 32129000 |
Ọja Specification
Ifarahan | Bia ofeefee kirisita lulú |
Ayẹwo | 99% |
Ibaraṣepọ laarin oogun antidiabetic, Metformin ati ọmọ malu thymus DNA (CT-DNA) ni (50mM Tris-HCl) ifipamọ ni a ṣe iwadi nipasẹ gbigba UV-Visible, fluorescence, spectroscopy CD ati awọn wiwọn viscosity.Ninu awọn ẹkọ fluorimetric, enthalpy ati entropy ti iṣesi laarin oogun ati CT-DNA fihan pe iṣesi jẹ exothermic (ΔH = -35.4522 kJ mol (-1); ΔS = -49.9523 J mol (-1) K (-1). )).Awọn ijinlẹ isọdọkan ifigagbaga fihan pe oogun naa le tu Hoechst 33258 silẹ patapata.Eka naa ṣe afihan hyperchromism gbigba ni irisi UV-Vis rẹ pẹlu DNA.Iṣiro ibakan abuda, K (b), ti a gba lati awọn ẹkọ gbigba UV-Vis jẹ 8.3 × 10 (4) M (-1).Pẹlupẹlu, awọn iyipada ninu spectra CD ni iwaju ti oogun naa ṣe afihan imuduro ti apa ọtun B ti CT-DNA.Nikẹhin, awọn wiwọn viscosity fi han pe isọdọkan eka pẹlu CT-DNA le jẹ abuda oju-aye, nipataki nitori abuda groove.Copyright © 2012 Elsevier BV Gbogbo ẹtọ wa ni ipamọ.