Awọn ọja

Islet amyloid polypeptide (IAPP; ti a tun mọ ni amylin) jẹ iduro fun dida amyloid islet ni iru àtọgbẹ 2, ati pe majele ti IAPP ni a gbagbọ pe o ṣe alabapin si isonu ti sẹẹli β-cell ti o ni nkan ṣe pẹlu awọn ipele ipari ti àtọgbẹ 2 iru.Idasile amyloid Islet le tun ṣe ipa ninu ikuna alọmọ lẹhin gbigbe.IAPP jẹ iṣelọpọ bi prohormone, pro-islet amyloid polypeptide (proIAPP), ati ṣiṣe ni awọn granulu aṣiri ti awọn sẹẹli beta pancreatic.Awọn fọọmu ilana apakan ti proIAPP ni a rii ni awọn idogo amyloid;ohun akiyesi julọ jẹ agbedemeji aloku 48, proIAPP (1-48), eyiti o pẹlu itẹsiwaju-igbooro N-terminal, ṣugbọn eyiti o ti ni ilọsiwaju daradara ni C-terminus.Ṣiṣeto ti ko pari le ṣe ipa kan ninu iṣelọpọ amyloid islet nipasẹ igbega awọn ibaraẹnisọrọ pẹlu awọn proteoglycans sulfated ti matrix extracellular, eyiti, leteto, ṣe igbelaruge iṣelọpọ amyloid.A fihan pe fuchsin acid (3- (1--amino-3-methyl-5-sulphonatophenyl) -1- (4-amino-3-sulphonatophenyl) methylene) cyclohexa-1,4-dienesulphonic acid), rọrun. sulfonated triphenyl methyl itọsẹ, jẹ oludaniloju to lagbara ti idasile amyloid nipasẹ agbedemeji proIAPP(1-48).Awọn itọsẹ triphenyl methane ti o ni idiju diẹ sii ni iyara alawọ ewe FCF {ethyl-[4-[[4-[ethyl-[(3-sulfophenyl)methyl]amino]phenyl]-(4-hydroxy-2-sulfophenyl)methylidene]-1-cyclohexa -2,5-dienylidene] -[(3-sulfophenyl) methyl] azanium} tun ṣe idiwọ idasile amyloid nipasẹ IAPP ati agbedemeji sisẹ proIAPP.Awọn agbo ogun mejeeji ṣe idiwọ idasile amyloid nipasẹ awọn akojọpọ ti agbedemeji proIAPP ati awoṣe glycosaminoglycan heparan sulfate.Acid fuchsin tun ṣe idiwọ idasile amyloid ti o ni agbedemeji glycosaminoglycan nipasẹ IAPP ti o dagba.Agbara lati ṣe idiwọ idasile amyloid kii ṣe lasan nitori awọn agbo ogun ti o jẹ sulfonated, nitori inhibitor sulfonated ti amyloid-β, tramiprosate, kii ṣe oludena idasile amyloid nipasẹ proIAPP (1-48).