Cas Folic Acid: 59-30-3 99%
| Nọmba katalogi | XD90435 |
| Orukọ ọja | Folic Acid |
| CAS | 59-30-3 |
| Ilana molikula | C19H19N7O6 |
| Òṣuwọn Molikula | 441.40 |
| Awọn alaye ipamọ | Ibaramu |
| Ti irẹpọ Owo idiyele koodu | 29362900 |
Ọja Specification
| Ifarahan | Yellow tabi osan kirisita lulú |
| Ayẹwo | 99% |
| Omi | 5.0 - 8.5% |
| Chromatographic ti nw | <2.0% |
| Solubility | Aifọwọyi aifọkanbalẹ ninu omi ati ọpọlọpọ awọn olomi Organic.O dissolves ni dilute acids ati ni ipilẹ awọn solusan |
| Aloku lori Iginisonu | <0.3% |
Ninu iwadi yi, thermosensitive ati folate functionalized poly(ethylene oxide) -b-poly(propylene oxide) -b-poly(etylene oxide) -ploy(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) copolymer je sisepọ.Eto ati iwuwo molikula ti copolymer jẹ timo nipasẹ 1H NMR, FT-IR ati GPC, lẹsẹsẹ.Iwọn otutu ojutu pataki kekere (LCST) ti copolymer jẹ iwọn 39.8 C. Nipa lilo doxorubicin (DOX) gẹgẹbi oogun awoṣe, awọn micelles ti o kojọpọ DOX ti o ni idojukọ folate ni a ṣẹda siwaju sii lori copolymer.Awọn micelles ti o ṣofo ati DOX ti o kojọpọ ṣe afihan awọn apẹrẹ iyipo ti o fẹrẹẹ jẹ ati awọn iwọn ila opin wọn jẹ 35 nm ati 50 nm, lẹsẹsẹ.Awọn ihuwasi itusilẹ in vitro ti awọn micelles ti o kojọpọ DOX ni igbẹkẹle iwọn otutu ati pe oṣuwọn idasilẹ ti DOX ni iwọn 42 C (loke LCST) yiyara ju iyẹn lọ ni iwọn 37 C (ni isalẹ LCST).Pẹlupẹlu, awọn igbelewọn cytotoxicity ti DOX ọfẹ ati awọn micelles ti o kojọpọ DOX lori awọn laini sẹẹli alakan ara eniyan HeLa ati awọn laini sẹẹli akàn ẹdọfóró eniyan A549 ṣe afihan pe folate pọ si gbigba cellular ti awọn micelles laarin awọn sẹẹli ti a fojusi ti o tobi pupọ awọn olugba folate ti o han gbangba.
