Doxorubicin hydrochloride CAS: 25316-40-9 99% Osan-pupa Crystalline lulú
| Nọmba katalogi | XD90367 |
| Orukọ ọja | Doxorubicin hydrochloride |
| CAS | 25316-40-9 |
| Ilana molikula | C27H29NO11·HCl |
| Òṣuwọn Molikula | 579.98 |
| Awọn alaye ipamọ | 2 si 8 °C |
| Ti irẹpọ Owo idiyele koodu | 29419000 |
Ọja Specification
| OmiAkoonu | ≤ 4.0% |
| pH | 4.0-5.5 |
| Solubility | Tiotuka ninu: omi, methanol ati isotonic NaCl (aq).Solubility ti ko dara ni chloroform ati awọn olomi Organic miiran. |
| Awọn nkan ti o jọmọ | Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Ayẹwo | 99% |
| Awọn ohun elo ti o ku | Acetone ati oti: ≤2.5% / Acetone: ≤0.5% / Methanol: ≤500ppm |
| Eyikeyi miiran impurities | ≤ 0.5% |
| Lapapọ Awọn Aimọ | ≤ 2.0% |
| Crystallinity | Ni ibamu pẹlu USP |
| Ifarahan | Osan-pupa Crystalline lulú |
| Idanimọ | HPLC |
Awọn alaisan ti o ni P-glycoprotein ati HER2/neu (HER2) olugba-iṣafihan akàn igbaya pupọ nigbagbogbo ni awọn abajade ile-iwosan ti ko dara.Sibẹsibẹ, ko si ni iṣowo ti o wa awọn laini sẹẹli alakan igbaya ti o jẹ HER2/P-glycoprotein ni ilopo-rere, eyiti o ṣe idiwọ iwadii ni aaye yii. Laini sẹẹli alakan nipasẹ gbigbe iduroṣinṣin ti kasẹti-abuda ATP (ABC) ẹgbẹ idile B 1 (ABCB1) pupọ ti o ṣe koodu P-glycoprotein.ABCB1 awọn ipele ikosile pupọ ga julọ lẹhin gbigbe, eyiti o yori si ilosoke 40-agbo ni P-glycoprotein. ikosile.O yanilenu, gbigbe ti ABCB1 tun yorisi ilosoke diẹ ninu jiini HER2 ati awọn ipele ikosile amuaradagba.Iyipada ti ABCB1 pọ si awọn ipele ikosile P-glycoprotein ni pataki. Ọna ti a lo ninu rẹ fun idagbasoke laini sẹẹli yii jẹ deede fun iyara, induction iduroṣinṣin ti P-glycoprotein-mediated drug resistance akawe si awọn ọna aditional tr.Idanwo cytotoxicity in vitro ni imọran laini sẹẹli yii ni atako agbelebu si ọpọlọpọ awọn aṣoju chemotherapeutic.
