Dirhodium tetraacetate CAS: 15956-28-2 99% Awọn kirisita alawọ-dudu
| Nọmba katalogi | XD90641 |
| Orukọ ọja | Dirhodium tetraacetate |
| CAS | 15956-28-2 |
| Ilana molikula | C8H12O8Rh2 |
| Òṣuwọn Molikula | 441.987 |
| Awọn alaye ipamọ | Ibaramu |
| Ti irẹpọ Owo idiyele koodu | 28439000 |
Ọja Specification
| Ifarahan | Awọn kirisita alawọ-dudu |
| Ayẹwo | 99% |
Awọn ibaraẹnisọrọ N7/O6 equatorial abuda ti eka antitumor ti nṣiṣe lọwọ Rh (2) (OAc) (4) (H (2)O) (2) (OAc (-) = CH (3) CO (2) (-)) pẹlu ajẹkù DNA d (GpG) ni a ti pinnu laiseaniani nipasẹ NMR spectroscopy.Awọn ipinnu crystallographic X-ray ti tẹlẹ ti ori-si-ori (HH) ati ori-si-tail (HT) awọn adducts ti dirhodium tetraacetate pẹlu 9-ethylguanine (9-EtGH) ṣe afihan afarapọ N7 / O6 guanine nucleobases ti a ko ri tẹlẹ ti o kọja Rh. -Rh iwe adehun.Awọn isansa ti protonation N7 ni pH kekere ati ilosoke akiyesi ni acidity ti N1-H (pK(a) to 5.7 bi akawe si 8.5 fun N7 nikan ti a dè Pilatnomu adducts), daba nipasẹ awọn titrations gbára pH ti purine H8 (1). )H NMR resonances fun Rh (2) (OAc) (2) (9-EtG) (2) ati Rh (2) (OAc) (2-) [d (GpG)], ni ibamu pẹlu bidentate N7/O6 abuda ti guanine nucleobases.Awọn iye pK (a) ti a pinnu fun N1-H (de) protonation, lati awọn ikẹkọ igbẹkẹle pH ti C6 ati C2 (13) C NMR resonances fun Rh (2) (OAc) (2) (9-EtG) ( 2) isomers, concur pẹlu t hose ti o wa lati awọn titration resonance H8 (1) H NMR.Ifiwera ti (13) C NMR resonances ti C6 ati C2 fun dirhodium adducts Rh (2) (OAc) (2) (9-EtG) (2) ati Rh (2) (OAc) (2) [d (GpG) )] pẹlu awọn isọdọtun ti o baamu ti awọn ligands ti ko ni asopọ [ni pH 7.0 fun 9-EtGH ati pH 8.0 fun d (GpG)], ṣe afihan awọn iṣipopada downfield pataki ti Deltadelta to 11.0 ati 6.0 ppm fun C6 ati C2, lẹsẹsẹ;awọn iṣipopada igbehin ṣe afihan ipa ti asopọ O6 si awọn ile-iṣẹ dirhodium ati imudara ti o tẹle ni acidity ti N1-H.Awọn giga-agbelebu H8/H8 ROE ti o lagbara ni 2D ROESY NMR spectrum ti Rh (2) (OAc) (2) [d (GpG)] tọkasi eto ori-si-ori ti awọn ipilẹ guanine.Rh (2) (OAc) (2) [d (GpG)] adduct ṣe afihan awọn olutọpa ọwọ ọtun meji pataki, HH1 R ati HH2 R, pẹlu HH1 R ni igba mẹta lọpọlọpọ ju HH2 R dani. adducts ṣe afihan ifasilẹ ti awọn oruka suga suga 5'-G si C3'-endo (N-type), idaduro C2'-endo (S-type) conformation fun 3'-G sugar ring gs, ati iṣalaye egboogi pẹlu ọwọ si awọn ifunmọ glycosyl.Awọn ẹya ara ẹrọ ti a gba fun Rh (2) (OAc) (2)) [d (GpG)] nipasẹ ọna ti NMR spectroscopy jẹ iru awọn ti cis-[Pt (NH (3))) (2)) [d ( GpG)]] ati awọn ẹkọ-iṣaro awoṣe molikula.
