Awọn ọja

Bromelain (BR) jẹ protease cysteine ​​kan pẹlu awọn ipa inhibitory lori yomijade ifun ati igbona.Sibẹsibẹ, awọn ipa rẹ lori motility ifun jẹ eyiti a ko ṣawari pupọ.Bayi, a ṣe iwadi ni ipa ti agbo-ara ti o gba ọgbin yii lori ifunmọ ifun ati gbigbe ni awọn eku. Ibaṣepọ in vitro ni a ṣe ayẹwo nipasẹ gbigbona ileum ti o ya sọtọ, ninu iwẹ ara, pẹlu acetylcholine, barium chloride, tabi itanna aaye itanna.Motility ni vivo ni a ṣe iwọn nipasẹ iṣiro pinpin ti ami ami fluorescent ti a nṣakoso ẹnu lẹba ifun kekere.A tun ṣe ayẹwo irekọja ni awọn ipinlẹ pathophysiologic ti o fa nipasẹ epo croton yellow pro-inflammatory tabi nipasẹ oluranlowo diabetogenic streptozotocin.Bromelain ṣe idiwọ awọn ihamọ ti o fa nipasẹ awọn orisirisi agbo ogun spasmogenic ni ile asin pẹlu iru agbara.Ipa antispasmodic ti dinku tabi koju nipasẹ inhibitor enzyme proteolytic, gabexate (15 × 10 (-6) mol L (-1) , protease-activated r eceptor-2 (PAR-2) antagonist, N (1) -3 -methylbutyryl-N (4) -6-aminohexanoyl-piperazine (10 (-4) mol L (-1) phospholipase C (PLC) inhibitor, neomycin (3 × 10 (-3) mol L (-1) ) , ati phosphodiesterase 4 (PDE4) inhibitor, rolipram (10 (-6) mol L (-1)).Ni vivo, BR fẹfẹ idilọwọ motility ni awọn ipinlẹ pathophysiologic ni ọna ti o ni imọlara PAR-2-antagonist. Awọn data wa daba pe BR ṣe idiwọ motility intestinal - ni pataki ni awọn ipo pathophysiologic - pẹlu ẹrọ ti o ṣee ṣe pẹlu awo PAR-2 ​​ati PLC ati PDE4 bi intracellular awọn ifihan agbara.Bromelain le jẹ apopọ asiwaju fun idagbasoke awọn oogun titun, ni anfani lati ṣe deede motility ifun ni iredodo ati àtọgbẹ.