Bisbenzimide H33342 Cas: 23491-52-3 Yellow powder
| Nọmba katalogi | XD90522 |
| Orukọ ọja | Bisbenzimide H33342 |
| CAS | 23491-52-3 |
| Ilana molikula | C27H28N6O · 3HCl |
| Òṣuwọn Molikula | 561.93 |
| Awọn alaye ipamọ | -15 si -20 °C |
| Ti irẹpọ Owo idiyele koodu | 32129000 |
Ọja Specification
| Ifarahan | Iyẹfun ofeefee |
| Ayẹwo | 99% |
Metabolite ti kokoro-arun inu ti ginseng protopanaxadiol saponin, 20-O- (β-D-glucopyranosyl) -20 (S) -protopanaxadiol (compound K), ti royin lati fa apoptosis ni ọpọlọpọ awọn sẹẹli alakan.Bibẹẹkọ, awọn ọna ṣiṣe kongẹ ti o fa nipasẹ agbo-ara K ninu awọn sẹẹli hepatocellular carcinoma eniyan (HCC) ko ṣiyemọ.Lati le ṣe ayẹwo awọn ilana apoptotic ti o ṣeeṣe, a ṣe iwadii ipa anticancer ti yellow K ni MHCC97-H.Ayẹwo MTT fihan pe agbo-ara K ṣe idinamọ ilọsiwaju ti awọn sẹẹli MHCC97-H pẹlu majele ti o kere diẹ ninu awọn sẹẹli hepatoma deede.Ilọsiwaju yiyipo sẹẹli ati abawọn sẹẹli ṣe afihan ilosoke ninu ida-ipin G1 apoptotic.Itoju ti MHCC97-H pẹlu yellow K tun fa idinku ninu agbara membran mitochondrial (Δψm) ati ibajẹ DNA.Iwadi siwaju sii fihan pe yellow K upregulated Fas, FasL, Bax/Bcl-2 ratio ati downregulated pro-caspase-9, pro-caspase-3 ni ọna ti o gbẹkẹle iwọn lilo, ati pe o tun ṣe idiwọ Akt phosphorylation.Awọn abajade wọnyi daba pe agbo-ara K ni pataki ṣe idiwọ ilọsiwaju sẹẹli ati fa apoptosis ninu awọn sẹẹli MHCC97-H nipasẹ Fas- ati mitochondria-mediated caspase-ti o gbẹkẹle awọn ipa ọna ninu awọn sẹẹli HCC eniyan.
