![Bis[2-Hydroxyethyl] imino Tris-(Hydroxymethyl)-methane Cas: 6976-37-0 99% Aworan Ifihan](http://cdn.globalso.com/xdbiochems/6976-37-0.jpg)
Bis[2-Hydroxyethyl] imino Tris-(Hydroxymethyl)-methane Cas: 6976-37-0 99%
| Nọmba katalogi | XD90111 |
| Orukọ ọja | BIS-TRIS (Bis (2-hydroxyethyl) amino-tris (hydroxymethyl) methane) |
| CAS | 6976-37-0 |
| Ilana molikula | C8H20NO5 |
| Òṣuwọn Molikula | 210.2476 |
| Awọn alaye ipamọ | Ibaramu |
| Ti irẹpọ Owo idiyele koodu | 2922190090 |
Ọja Specification
| Awọn irin ti o wuwo | <10ppm |
| Aloku lori Iginisonu | <0.1% |
| Pka | 6.3-6.7 |
| Ifarahan | Funfun Crystalline Powder |
| Solubility (1M ni H20) | Ko o ati Pari |
| pH (1M ninu H2O) | 9.0-11.0 |
| Ọrinrin (LOD) | 1.0% ti o pọju. |
| Ayẹwo (Titration lori ipilẹ gbigbẹ) | 99.0% iṣẹju. |
Buffer, ti a lo fun wiwa ti creatine-creatinase;tun lo fun aabo to munadoko ti haemoglobin ni didi-gbigbẹ;catholyte, lo ninu IEF/2-D jeli electrophoresis.
Factor neurotrophic ti o ni laini sẹẹli Glial (GDNF) jẹ oludena agbara ti agbara ethanol ati ifasẹyin, ati GDNF heterozygous knockout eku ṣe afihan ifamọ ere pọ si ethanol ati jẹun ethanol diẹ sii lẹhin akoko abstinence ju awọn ẹlẹgbẹ egan wọn lọ.Nibi, a ṣe idanwo boya ethanol ṣe iyipada ikosile GDNF ni agbegbe ventral tegmental (VTA; aaye GDNF ti iṣe) ati / tabi accumbens nucleus (NAc; orisun akọkọ ti GDNF), ati bi o ba jẹ bẹ, pinnu ipa ti ifosiwewe idagba ailopin. ni ilana ti lilo ethanol.Isakoso eto ti ethanol pọ si ikosile GDNF ati awọn ipele amuaradagba ninu VTA, ṣugbọn kii ṣe NAc.Ni afikun, awọn ipele GDNF ni a gbega lẹhin igba mimu ethanol ninu awọn eku ti o jẹ ethanol ninu ilana yiyan igo meji-iwọle lainidii fun ọsẹ 1, ṣugbọn kii ṣe awọn ọsẹ 7.Idinku ti o tẹle awọn ọsẹ 7 ti gbigbe ethanol ti o pọju dinku awọn ipele GDNF, lakoko akoko mimu ọti-ẹmu ethanol kukuru kan ti o tẹle ikosile ti GDNF ti a ṣe atunṣe.Ni pataki, ikọlu ti GDNF laarin VTA nipa lilo adenovirus ti n ṣalaye irun kukuru kukuru RNA jẹ ki o pọsi ti mimu ethanol nipasẹ awọn eku ethanol-naïve, ṣugbọn kii ṣe nipasẹ awọn eku pẹlu itan-akọọlẹ ti lilo ethanol pupọ.Awọn abajade wọnyi daba pe lakoko awọn iriri mimu ethanol akọkọ, GDNF ni VTA ti pọ si ati aabo fun idagbasoke ti gbigbemi ethanol pupọ.Bibẹẹkọ, idahun aabo ifosiwewe idagba si ethanol ba lulẹ lẹhin gbigbemi ethanol ti o pọ ju ati yiyọ kuro, ti o yọrisi itẹramọṣẹ, agbara ethanol pupọju.
