Albendazole Cas: 54965-21-8
| Nọmba katalogi | XD91873 |
| Orukọ ọja | Albendazole |
| CAS | 54965-21-8 |
| Molecular Formula | C12H15N3O2S |
| Òṣuwọn Molikula | 265.33 |
| Awọn alaye ipamọ | 2-8°C |
| Ti irẹpọ Owo idiyele koodu | 29332990 |
Ọja Specification
| Ifarahan | Funfun okuta lulú |
| Asay | 99% iṣẹju |
| Ojuami yo | 208-210 °C |
| iwuwo | 1.2561 (iṣiro ti o ni inira) |
| refractive atọka | 1.6740 (iṣiro) |
| solubility | Ni iṣe ti ko ṣee ṣe ninu omi, tiotuka larọwọto ni anhydrous formic acid, tiotuka die-die ni methylene kiloraidi, ni iṣe ti ko ṣee ṣe ni ethanol (96 fun ogorun). |
| pka | 10.72± 0.10 (Asọtẹlẹ) |
| Omi Solubility | 0.75mg/L(209ºC) |
Albendazole jẹ oogun ti a lo lati tọju awọn akoran ti o fa nipasẹ awọn parasites.A le fun ni lati ṣe itọju ikolu ọpọlọ ti o ṣọwọn (neurocysticercosis) tabi a le fun ni lati tọju ikolu parasitic ti o fa igbuuru pataki (microsporidiosis).
Itọsẹ ti benzimidazole, albendazole jẹ oogun ti o ni irisi antihelmintic gbooro.O ṣe afihan ipa antihelmintic lodi si awọn cestodes ifura ati awọn nematodes nipa didi ilana gbigba glukosi nipasẹ awọn parasites, eyiti o han ni idinku awọn ifiṣura glycogen ati idinku atẹle ni ipele adenosintriphophate.Bi abajade, parasite naa duro gbigbe ati ku.O ti lo lori ikolu ti Acaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, ati Trichuris trichiura.Awọn itumọ ti oogun yii jẹ SKF 62979 ati awọn miiran.
Methyl 5- (propylthio) -2-benzimidazolecarbamate (Eskazole, Zentel) jẹ anthelmintic ti o gbooro ti kii ṣe ọja lọwọlọwọ ni Ariwa America.O wa lati ọdọ olupese lori ipilẹ lilo aanu.Albendazole jẹ lilo jakejado agbaye fun itọju ikolu ti intestinalnematode.O munadoko bi itọju iwọn lilo ẹyọkan fun ascariasis, New ati Old World hookworm àkóràn, ati trichuriasis.Itọju iwọn lilo pupọ pẹlu albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, ati arun hydatid.Imudara ti albendazole lodi si awọn kokoro-iworms (cestodes) jẹ iyipada diẹ sii ati ki o kere si.
Albendazole waye bi funfun crystalline lulú ti o jẹ fere insoluble ninu omi.Gbigba ẹnu ti albendazoleis ti mu dara si nipasẹ ounjẹ ọra.Oogun naa gba iyara ati iṣelọpọ agbara-akọkọ lọpọlọpọ si sulfoxide, eyiti o jẹ fọọmu ti nṣiṣe lọwọ ni pilasima.Imukuro idaji-aye ti sulfoxide wa lati awọn wakati 10 si 15.Biliaryexcretion ti o pọju ati atunlo enterohepatic ti albendazolesulfoxide waye.Albendazole ni gbogbogbo jẹ ifarada daradara ni itọju iwọn lilo ẹyọkan fun awọn nematodes ifun.Iwọn giga, itọju ailera gigun ti o nilo fun itọju ailera arun ti clonorchiasis orechinococcal le ja si awọn ipa buburu gẹgẹbi irẹwẹsi ọra inu, igbega ti awọn ensaemusi ẹdọ, ati alopecia.
Albendazole ni iṣẹ ṣiṣe ti o gbooro lodi si awọn nematodes ifun ati awọn cestodes, bakanna bi awọn iṣan ẹdọ Opisthorchis sinensis, Opisthorchis viverrini, ati Clonorchis sinensis.O tun ti lo ni aṣeyọri lodi si Giardia lamblia.Albendazole jẹ itọju ti o munadoko ti arun cyst hydatid (echinococcosis), paapaa nigbati o ba wa pẹlu praziquantel.O tun jẹ doko ni atọju cerebral ati ọpa ẹhin neurocysticercosis, paapaa nigba ti a fun ni pẹlu dexamethasone. Albendazole ni a ṣe iṣeduro fun itọju gnathostomiasis.
