5,5-Dithiobis (2-nitrobenzoic acid) Cas: 69-78-3 99% koriko ofeefee lulú
| Nọmba katalogi | XD90158 |
| Orukọ ọja | 5,5-Dithiobis (2-nitrobenzoic acid) |
| CAS | 69-78-3 |
| Ilana molikula | C14H8N2O8S2 |
| Òṣuwọn Molikula | 396.35 |
| Awọn alaye ipamọ | Ibaramu |
| Ti irẹpọ Owo idiyele koodu | 29309098 |
Ọja Specification
| Nọmba katalogi | XD90158 |
| Orukọ ọja | 5,5-Dithiobis (2-nitrobenzoic acid) |
| CAS | 69-78-3 |
| Ilana molikula | C14H8N2O8S2 |
| Òṣuwọn Molikula | 396.35 |
| Awọn alaye ipamọ | Ibaramu |
| Ti irẹpọ Owo idiyele koodu | 29309098 |
Idasile Acyl-CoA bẹrẹ iṣelọpọ ọra acid cellular.Acyl-CoAs jẹ ipilẹṣẹ nipasẹ ligation ti ọra acid si Coenzyme A ti o ni ilaja nipasẹ idile nla ti awọn synthetases acyl-CoA (ACS).Lọna miiran, awọn acyl-CoAs le jẹ hydrolyzed nipasẹ idile kan ti acyl-CoA thioesterases (ACOT).Nibi, a ti pinnu ilana transcriptional ti gbogbo ACS ati ACOT ensaemusi kọja awọn tissues ati ni esi si awọn perturbations ti iṣelọpọ.A wa awọn ilana ti isọdọkan laarin ati laarin awọn idile apilẹṣẹ bi daradara bi ilana ọtọtọ ti o waye ni ọna tisura- ati ti ara-ara-ara.Nitori awọn ayipada ti a ṣe akiyesi ni ACOT mRNA pq gigun ati lọpọlọpọ amuaradagba ninu ẹdọ ati adipose tissu, a pinnu abajade ti jijẹ iṣẹ-ṣiṣe thioesterase gigun-gun cytosolic lori iṣelọpọ acid ọra ninu awọn tisọ wọnyi nipa jiṣẹ awọn eku transgenic overexpressing mutant hyperactive ti Acot7 ninu ẹdọ tabi adipose tissue.Ilọpo meji cytosolic acyl-CoA thioesterase aṣayan iṣẹ-ṣiṣe kuna lati daabobo mic e lati isanraju ounjẹ ti o fa, ẹdọ ọra tabi resistance insulin, sibẹsibẹ, ijuwe pupọ ti Acot7 ninu awọn adipocytes ti jẹ ki eku tutu tutu.Papọ, awọn data wọnyi daba awọn ipo iyasọtọ ti ilana ti awọn ensaemusi ACS ati ACOT ati pe awọn ensaemusi wọnyi ṣiṣẹ ni aṣa iṣakojọpọ lati ṣakoso iṣelọpọ acid ọra ni ọna ti o gbẹkẹle ara.
