5-Nitro-1,10-phenanthroline CAS:4199-88-6 Ina ofeefee si kirisita brown
| Nọmba katalogi | XD90385 |
| Orukọ ọja | 5-Nitro-1,10-phenanthroline |
| CAS | 4199-88-6 |
| Ilana molikula | C12H7N3O2 |
| Òṣuwọn Molikula | 225.21 |
Ọja Specification
| Ojuami Iyo | 200 - 203 °C |
| Ayẹwo | 99% |
| Ifarahan | Ina ofeefee to brown gara |
Pilatnomu mẹẹdogun(II) -metalointercalators ti o da lori ni a ti ṣajọpọ ti o lo awọn ligands 1,10-phenanthroline (phen) ti o rọpo, pẹlu 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) ati dipyrido [3,2-d : 2', 3'-f] quinoxaline (dpq), ati achiral ethylenediamine (en) ati awọn ligands chiral ancillary 1S,2S-diaminocyclohexane (S, S-dach) ati 1R,2R-diaminocyclohexane (R, R-dach) .Cytotoxicity wọn ni laini sẹẹli leukemia murine L1210 ni a pinnu nipa lilo awọn idanwo idinamọ idagbasoke.Awọn eka irin cytotoxic julọ ni awọn ti o ni S, S-dach ancillary ligands ati 5-CH3-phen intercalating ligands ninu.Ọkan metallointercalator [Pt (5-CH3-phen) (S, S-dach)] Cl2 (5MESS), ṣe afihan ilosoke 5-10 ni cytotoxicity ni akawe si oluranlowo ile-iwosan cisplatin.Lati awọn adanwo abuda DNA o dabi ẹni pe ko si iyatọ pataki laarin eyikeyi ninu awọn eka irin, ti o nfihan pe bẹni isunmọ DNA tabi ipo abuda/DNA adduct ti a ṣẹda jẹ ipinnu nikan ti cytotoxicity ti idile Pilatnomu (II) ti o da. metallointercalators.
