Awọn ọja

(3R, 4R) -1- (tert-Butoxycarbonyl) -4-methylpyrrolidine-3-carboxylic acid, ti a tun mọ ni Boc-4-methylproline, jẹ ohun elo kemikali ti o gbajumo ni aaye ti iṣelọpọ Organic, paapaa ni iṣelọpọ ti peptides ati peptidomimetics fun awọn oriṣiriṣi awọn ohun elo.Ọkan ninu awọn lilo akọkọ ti Boc-4-methylproline jẹ bi ẹgbẹ idaabobo fun ẹgbẹ amino ti amino acids nigba iṣelọpọ peptide.Awọn ẹgbẹ aabo jẹ awọn iyipada igba diẹ ti o daabobo awọn ẹgbẹ iṣẹ ṣiṣe kan pato ti awọn moleku lati ṣe idiwọ awọn aati ti aifẹ lakoko ilana sintetiki.Ni iṣelọpọ peptide, Boc-4-methylproline ti wa ni iṣẹ bi ẹgbẹ aabo fun ẹgbẹ amine, gbigba fun asomọ yiyan ti awọn amino acids miiran lati ṣe ilana peptide ti o fẹ.Boc-4-methylproline tun ṣe iranṣẹ bi bulọọki ile chiral ninu kolaginni ti Oniruuru agbo pẹlu o pọju ti ibi akitiyan.Gẹgẹbi apopọ chiral, o ni stereocenter kan, ti o funni ni awọn enantiomers meji: (3R,4R) -Boc-4-methylproline ati (3S, 4S) -Boc-4-methylproline.Enantiomer kọọkan le ṣe afihan oriṣiriṣi awọn ohun-ini elegbogi ati awọn ibaraenisepo pẹlu awọn ibi-afẹde ti ibi.Nipa lilo Boc-4-methylproline bi ohun elo ti o bẹrẹ, awọn chemists le wọle si ọpọlọpọ awọn agbo ogun chiral fun wiwa ati idagbasoke oogun.Pẹlupẹlu, awọn itọsẹ Boc-4-methylproline ti ṣe afihan antimicrobial, antiviral, and anticancer.Awọn agbo ogun wọnyi ni a ti ṣe iwadii fun agbara wọn bi awọn aṣoju iwosan lodi si ọpọlọpọ awọn pathogens, pẹlu kokoro arun, awọn ọlọjẹ, ati awọn sẹẹli alakan.Nipa iyipada ọna ti Boc-4-methylproline ati iṣiro awọn itọsẹ rẹ, awọn oniwadi le ṣawari agbara wọn gẹgẹbi awọn agbo-ogun asiwaju tabi awọn ohun elo ti o ni iṣiro fun apẹrẹ oògùn. ninu awọn ẹda ti peptidomimetics.Peptidomimetics jẹ awọn agbo ogun ti o fara wé ọna ati iṣẹ ti awọn peptides ṣugbọn ni iduroṣinṣin imudara ati awọn ohun-ini elegbogi.Boc-4-methylproline le ṣiṣẹ bi bulọọki ile ni apẹrẹ ati iṣelọpọ ti peptidomimetics, gbigba fun idagbasoke ti awọn itọju aramada pẹlu ilọsiwaju bioavailability ati pato ibi-afẹde.Ni akojọpọ, (3R,4R) -1- (tert-Butoxycarbonyl) 4-methylpyrrolidine-3-carboxylic acid, tabi Boc-4-methylproline, jẹ ẹya-ara ti o wapọ ti a lo ni lilo pupọ ni iṣelọpọ Organic.Ipa rẹ gẹgẹbi ẹgbẹ aabo ni iṣelọpọ peptide, ati awọn ohun-ini chiral rẹ, jẹ ki o jẹ bulọọki ile ti ko niye fun ṣiṣẹda awọn peptides, peptidomimetics, ati awọn agbo ogun chiral.Awọn itọsẹ ti Boc-4-methylproline ni a ṣe iwadii fun awọn iṣẹ ṣiṣe ti ibi-aye ti o pọju wọn, eyiti o pẹlu antimicrobial, antiviral, ati awọn ohun-ini anticancer.Iwadi ti o tẹsiwaju ati ĭdàsĭlẹ ni lilo Boc-4-methylproline ni apẹrẹ oogun ṣe alabapin si idagbasoke ti awọn aṣoju iwosan tuntun ati ilọsiwaju oye wa ti awọn ilana iṣe ti ibi.