Awọn ọja

3-tert-Butoxycarbonylphenylboronic acid, ti a tun mọ ni Boc-phenylboronic acid, jẹ itọsẹ acid boronic pataki pẹlu awọn ohun elo pataki ni iṣelọpọ Organic ati kemistri oogun. Ọkan ninu awọn lilo akọkọ ti 3-tert-Butoxycarbonylphenylboronic acid jẹ bi ẹgbẹ aabo ni Organic Organic. kolaginni.Ẹgbẹ tert-butyloxycarbonyl (BOC) jẹ iṣẹ ti o wọpọ lati daabobo awọn ẹgbẹ iṣẹ ṣiṣe amine fun igba diẹ lakoko awọn aati pupọ.Nipa sisopọ ẹgbẹ BOC si ara amine, ifasilẹ ti amine ti dinku, gbigba fun awọn aati yiyan ni awọn ipo miiran lori moleku naa.Ẹgbẹ BOC le ni irọrun kuro labẹ awọn ipo kekere, nitorinaa ṣafihan iṣẹ ṣiṣe amine atilẹba.Ilana ẹgbẹ idabobo yii n jẹ ki iṣelọpọ daradara ti awọn ohun alumọni Organic eka, gẹgẹbi awọn oogun ati awọn ọja adayeba.Pẹlupẹlu, 3-tert-Butoxycarbonylphenylboronic acid ṣiṣẹ bi reagent ti o niyelori fun didasilẹ mnu erogba-erogba.Awọn acids Boronic, pẹlu Boc-phenylboronic acid, ni imurasilẹ ṣe agbekalẹ awọn esters boronate nigba ti a ṣe pẹlu awọn nucleophiles, gẹgẹbi awọn ọti-lile tabi amines.Awọn esters boronate wọnyi le ṣe ọpọlọpọ awọn iyipada, pẹlu Suzuki-Miyaura awọn aati isọpọ-agbelebu, awọn idapọ Negishi, ati awọn idapọ Stille.Awọn aati wọnyi jẹ ki idasile ti awọn ohun alumọni eleto pẹlu ọpọlọpọ awọn ilana fidipo ati awọn ẹgbẹ iṣẹ.Boc-phenylboronic acid jẹ iwulo paapaa fun iṣafihan awọn ohun elo phenylboronic acid sinu awọn ohun elo ibi-afẹde. Ni afikun, Boc-phenylboronic acid ṣe ipa pataki ninu kemistri oogun.Iṣẹ-ṣiṣe acid boronic le ṣe ajọṣepọ ni yiyan pẹlu awọn diol tabi awọn ẹgbẹ iṣẹ-ifọwọsi boronate ester ni awọn ibi-afẹde ti ibi, ti o mu ki apẹrẹ ti awọn inhibitors enzyme ti o da lori boronate ati awọn ligands olugba.Boc-phenylboronic acid le ṣepọ si awọn inhibitors kekere-molecule, peptides, tabi prodrugs lati fun awọn ohun-ini ti o fẹ tabi mu iyasọtọ ibi-afẹde sii.Awọn agbo ogun ti o da lori boronate wọnyi ti ṣe afihan ileri ni itọju ti awọn oriṣiriṣi awọn arun, pẹlu akàn, diabetes, and inflammation.Ni akojọpọ, 3-tert-Butoxycarbonylphenylboronic acid, tabi Boc-phenylboronic acid, wa awọn ohun elo ti o yatọ si ni iṣelọpọ Organic ati kemistri oogun.Ẹgbẹ BOC rẹ n ṣiṣẹ bi ẹgbẹ aabo, gbigba fun awọn aati yiyan ni awọn ipo miiran lori moleku.Pẹlupẹlu, iṣẹ ṣiṣe boronic acid n jẹ ki awọn idasile isunmọ erogba-erogba ṣiṣẹ, ni irọrun iṣelọpọ ti awọn ohun elo Organic eka.Ni afikun, Boc-phenylboronic acid ṣe ipa pataki ninu kemistri oogun, nibiti o ti lo ninu apẹrẹ ti awọn inhibitors enzyme-orisun boronate ati awọn ligands olugba.Lapapọ, Boc-phenylboronic acid jẹ reagent ti o niyelori ti o ṣe alabapin si awọn ilọsiwaju ninu kemistri sintetiki ati iwadii wiwa oogun.