2-Amino-3- (4-hydroxyphenyl) Propanoic acid Cas: 556-03-6 99% Crystalline
| Nọmba katalogi | XD90297 |
| Orukọ ọja | 2-Amino-3- (4-hydroxyphenyl) propanoic acid |
| CAS | 556-03-6 |
| Ilana molikula | C9H11NO3 |
| Òṣuwọn Molikula | 181.18854 |
| Awọn alaye ipamọ | Iwọn otutu yara |
| Ti irẹpọ Owo idiyele koodu | 29225000 |
Ọja Specification
| Ayẹwo | 99% |
| Ifarahan | Crystalline |
Cerebral dopamine neurotrophic ifosiwewe (CDNF) amuaradagba ti han lati daabobo ipa ọna dopaminergic nigrostriatal nigba ti a fun ni bi awọn infusions intrastriatal ni eku ati awọn awoṣe Asin ti Arun Pakinsini (PD).Ninu iwadi yii, a ṣe ayẹwo ipa neuroprotective ti CDNF ti a fi jiṣẹ pẹlu viral ti o ni ibatan adeno ti o ni ibatan (AAV) serotype 2 vector ni rat 6-hydroxydopamine (6-OHDA) awoṣe ti PD.AAV2 fekito fifi koodu CDNF, glial cell laini-ti ari neurotrophic ifosiwewe (GDNF), tabi amuaradagba Fuluorisenti alawọ ewe ni abẹrẹ sinu striatum eku.Atupalẹ ikosile Amuaradagba fihan pe fekito AAV2 wa daradara fi jiini ifosiwewe neurotrophic sinu ọpọlọ ati pe o dide si ikosile pipẹ ti awọn ọlọjẹ.Ni ọsẹ meji lẹhin abẹrẹ fekito AAV2, 6-OHDA ni itasi sinu striatum eku, ṣiṣẹda ibajẹ ilọsiwaju ti eto dopaminergic nigrostriatal.Itoju pẹlu AAV2-CDNF yorisi idinku idinku ninu amphetamine-induced ipsilateral rotations nigba ti o pese ed nikan apa kan Idaabobo ti tyrosine hydroxylase (TH) -immunoreactive ẹyin ni eku substantia nigra pars compacta ati TH-reactive awọn okun ni striatum.Awọn abajade lati inu iwadi yii pese awọn ẹri afikun pe CDNF le jẹ itọju ti o pọju ti aisan Parkinson
