2- (3,5-Dimethyl-4- (2- (pyrrolidin-1-yl) ethoxy) phenyl) -5,7-dimethoxyquinazolin-4 (3H) - ọkan Cas: 1044871-04-6
Nọmba katalogi | XD90961 |
Orukọ ọja | 2- (3,5-Dimethyl-4- (2- (pyrrolidin-1-yl) ethoxy) phenyl) -5,7-dimethoxyquinazolin-4 (3H) -ọkan |
CAS | 1044871-04-6 |
Ilana molikula | C24H29N3O4 |
Òṣuwọn Molikula | 423.5 |
Awọn alaye ipamọ | |
Ti irẹpọ Owo idiyele koodu |
Ọja Specification
Ifarahan | |
Ayẹwo | |
Boiling ojuami | 612.6± 65.0 °C(Asọtẹlẹ) |
iwuwo | 1.25± 0.1 g/cm3(Asọtẹlẹ) |
olùsọdipúpọ acidity | (pKa) 9.54± 0.20 (Asọtẹlẹ) |
RVX-297 jẹ alagbara ti o ga, oludanujẹ BET ti nṣiṣe lọwọ ẹnu yiyan fun BD2.Awọn IC50 ti RVX-297 fun BRD2(BD2), BRD3(BD2), ati BRD4(BD2) jẹ 0.08, 0.05, ati 0.02 μM, lẹsẹsẹ.RVX-297 ṣe idiwọ ikosile ti ọpọlọpọ awọn jiini iredodo sẹẹli ti ajẹsara.Agbara ti RVX-297 ni awọn awoṣe preclinical ti iredodo nla ati autoimmunity.
Sunmọ